If you are considering using Cannabidiol (CBD), one thing that may have crossed your mind is – what is the most effective way to use it?.

CBD Bioavailability

There are several CBD products such as tinctures, lotions, oils, capsules, e-liquids, and so forth. Each has a unique consumption method, and every product is available in various CBD concentrations.

Bioavailability refers to the degree and absorption rate of the compound in the bloodstream.

In this regard, CBD bioavailability may vary depending on the type of product and the CBD concentration.

So how should I take CBD?

The intravenous administration is the most direct course to achieve the highest rate of bioavailability. The method requires injecting the compound straight to the bloodstream via the veins.

This method certainly delivers 100% of the CBD compound into the system, yet it is not the most preferred option for the obvious reason.

Anybody who does not wish to stick themselves with a needle may consider other ways.

Oral Consumption

Oral consumption basically means taking something via the mouth. As far as CBD is concerned, oral consumption includes taking beverages, capsules, and edibles.

This method of consumption provides particular benefits, yet remember that anything eaten will need to go through the processes of digestion and metabolism, which could significantly lower its bioavailability.

Research conducted in 1986 said that the bioavailability of substances consumed orally is at 6%. Another study in 2009 said that the rate ranges from 4% to 20%. The findings are significantly different from one another yet they both point to a bioavailability that is quite too low. The most optimistic scenario is a 20% bioavailability rate.

In a practical sense, in case you take a capsule containing 100 mg of CBD, just about 20mg of the compound actually gets into your bloodstream.

Sublingual Consumption

This method of consumption involves placing the CBD oil under the tongue for the sublingual gland to absorb the compound directly into the bloodstream. The most common way to do so include sprays, lozenges, and tinctures.

Considering that this method is more direct, the benefits of the CBD take effect faster than oral consumption. It also gives you a higher bioavailability rate since only a minimal portion of the compound is broken down by enzymes found in the saliva.

CBD bioavailability rate when consumed sublingually may range from 12% to 35%.


This method involves inhaling the compound directly into the lungs.

Considering that CBD enters directly into the lungs, the compound can then immediately get into the bloodstream, vaping has a higher bioavailability as a result of reduced breakdown rates.

Studies show that CBD bioavailability rates from vaping range from 34% to 46%. Other studies report nearly 60%. This means that it is one of the most effective ways of using CBD. It is also one of the most highly recommended methods.